Convenient synthesis of nucleoside 5'-triphosphates for RNA transcription.
نویسندگان
چکیده
By generating a selective phosphitylating reagent in situ, nucleoside 5'-triphosphates can be conveniently synthesized in one pot. This novel strategy without nucleoside protection has been developed to largely simplify synthesis of the nucleoside triphosphates. This demonstrated principle can be applied to the 5'-triphosphate synthesis of both native and modified nucleosides.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 28 شماره
صفحات -
تاریخ انتشار 2011